PROTACs (proteolysis-targeting chimeric molecules): A review and discussion of the technique and its application to therapies and drug discovery.
Kerstin Brachhold
Regulating Gene Expression: DNA Provides a Twist
DNA conformation can regulate gene expression, as discussed by Olga Zaytseva and Leonie Quinn in a review in BioEssays.
Hematopoiesis in the Bone Marrow Microenvironment: Of Cells, their Interactions, and Therapeutic Opportunities
Recent findings on the roles and identity of the bone marrow microenvironment and how these niches might be targeted in the case of diseases are discussed.
The Devil Fights Back: How the Tasmanian Devil Adapts to Transmissible Cancer
In their review in BioEssays, Beata Ujvari and colleagues review how the transmissible cancer termed ‘devil facial tumor disease’ affects life history adaptations in Tasmanian devils.
Engage and Move Forwards: Eukaryotic CMG Helicase Leads the Way at Replication Forks
In their review in BioEssays, Huilin Li and Michael O’Donnell discuss recent findings about the structure and function of the eukaryotic CMG helicase.
DNA Replication Revisited: Single-Molecule Analyses Reveal Its Highly Dynamic Nature
In their review in BioEssays, Karl Duderstadt and colleagues challenge the long-held view that DNA replication follows a single highly reproducible sequence of molecular events.
Horizontal Transfer of Transposable Elements
In their review in BioEssays, Jean Peccoud and colleagues discuss the challenges and prospects of analyzing horizontal transfer of transposable elements on a large scale.
MicroRNAs and RNA Editing: Roles in Cancer Initiation and Progression
A study on the mechanisms and effects of RNA and microRNA editing on the initiation and progression of cancer.
Aneuploidy and Chromosomal Instability: Their Relationship and Consequences
In their review in BioEssays, Klaske Schukken and Floris Foijer discuss the different concepts and consequences of chromosomal instability and aneuploidy.
Asleep or Awake? Deciphering the Molecular Mechanisms of Sleep Regulation
In their review in BioEssays, Shoi Shi and Hiroki Ueda review recent studies on sleep duration and homeostasis.