Injectable supramolecular hydrogel/microgel composite for controlling the delivery of therapeutic molecules to tissues after injury or disease, including cardiac tissue after myocardial infarction.
Therapeutics
The Complex Enzymology Of mRNA Decapping
Single stranded RNAs with a free 5′ monophosphate end are susceptible to rapid degradation. Transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) are stabilized by hairpin structures and by “hiding” their 5′ ends within complex protein structures.
Nanofactories: Evolution of Drug Delivery Systems
The required features of nanofactories, and current strategies for their design and fabrication.
Engineering Stealth Mode Nanoparticles for Enhanced Drug Delivery
Scientists graft multifunctional biopolymers on the outer surface of nanometric metal-organic frameworks to improve its furtiveness.
Insights for Heart Repair
The Hippo pathway’s role in heart development and regeneration.
Cover Art: Osteogenesis, Anti‐Inflammatory Nanotherapeutics & Bone Regeneration
Check out the latest covers of Advanced Healthcare Materials!
Context-Dependent Regulation of Receptor Tyrosine Kinases
Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.
Let it Shine: Light-Sensitive Designer Cells
A review of optogenetically engineered cells and their applications.
“Mushrooms”: Underrepresented, Yet Important Members Of The Body’s Microbial Garden
Mammalian barrier surfaces are densely populated by symbiont fungi in much the same way the former are colonized by symbiont bacteria. The fungal microbiota, otherwise known as the mycobiota, is increasingly recognized as a critical player in the maintenance of health and homeostasis of the host.
Bringing Sugar to the Core: A Core-Shell Solution to Insulin Replacement
Lipid bilayer-coated polymeric nanoparticles can at as a long-acting, glucose-responsive insulin delivery system in type-I diabetes.
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