A new type of 5′‐RNA cap was discovered, and in contrast to the specialized eukaryotic m7G cap, the novel caps are abundant cellular cofactors like NAD+.
Biosystems
Hall of Fame Highlight: Frank Caruso
Frank Caruso on nanomaterials for the future of medicine.
Insights into Transcriptome-Wide RNA population Dynamics
Cellular RNA levels are the result of a juggling act between RNA transcription, processing, and degradation. By tuning one or more of these parameters, cells can rapidly alter the available pool of transcripts in response to stimuli.
Methylated Cytosine: A Promising Regulator of RNA Function?
It is a well‐known fact that RNA is the target of a plethora of modifications which currently amount to over a hundred. The vast majority of these modifications was observed in the two most abundant classes of RNA, rRNA and tRNA. With the recent advance in mapping technologies, modifications have been discovered also in mRNA and in less abundant non‐coding RNA species.
First Study on Cold Atmospheric Plasma Treatment of ‘Dry’ Amino Acids
A team of German researchers conducted the first study on the direct exposure of cold atmospheric plasma on amino acids at dry conditions.
Noncanonical Features and Modifications on the 5′‐End of Bacterial sRNAs and mRNAs
Although many eukaryotic transcripts contain cap structures, it has been long thought that bacterial RNAs do not carry any special modifications on their 5′‐ends. In bacteria, primary transcripts are produced by transcription initiated with a nucleoside triphosphate and are therefore triphosphorylated on 5′‐ends.
Cover Art: Osteogenesis, Anti‐Inflammatory Nanotherapeutics & Bone Regeneration
Check out the latest covers of Advanced Healthcare Materials!
Context-Dependent Regulation of Receptor Tyrosine Kinases
Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.
Hall of Fame Highlight: Luis Liz-Marzán
Luis Liz-Marzán on nanoparticles, a concerning trend in science, and his future research plans.
Disassembling Solvation Free Energies into Local Contributions
Solvation free energies contribute to the driving force of molecular processes in solution and play a significant role for the relative stability of biomolecular conformations or the formation of complexes. Changes in solvation free energy are the origin of solvent‐mediated interactions such as the hydrophobic effect in water.
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