All organisms are subject to large amounts of genetic and environmental variation and have evolved mechanisms that allow them to function well in spite of these challenges. This property is generally referred to as robustness.
Life Science
Membraneless Nuclear Organelles and the Search for Phases Within Phases
An analysis of nuclear body protein disorder that suggests MLO proteomes are significantly more disordered than structured cellular features.
Fluorogenic Protein Systems: Labeling and Beyond
In their review published in BioEssays, Arnaud Gautier and Alison Tebo discuss new labeling protocols, actuation methods and biosensors based on fluorogenic protein systems.
Sex Determination: When Does It Start and How Might It Work?
In her article published in BioEssays, Nora Engel discusses how sex differences become established in early embryogenesis and how analyzing the underlying mechanisms can lead to a better understanding of sex differences in health and disease.
Translational Control By Poxviruses
Poxviruses are an unusual family of large double‐stranded (ds) DNA viruses that exhibit an incredible degree of self‐sufficiency and complexity in their replication and immune evasion strategies.
Noncanonical RNA‐capping: Discovery, Mechanism, and Physiological Role Debate
A new type of 5′‐RNA cap was discovered, and in contrast to the specialized eukaryotic m7G cap, the novel caps are abundant cellular cofactors like NAD+.
Hydra Model: Potential Insights into the Microbiota–Gut–Brain Axis
Alexander Klimovich and Thomas Bosch discuss current knowledge on the function of the nervous system in Hydra and the interactions between neurons and microbes.
New OCT System with Angiography for Everyday Clinical Use
A team of Russian scientists developed an OCT system with angiography for everyday clinical use.
Smallest Imaging System To-Date for Skin Diagnosis
A team of Spanish researchers developed a handheld skin imaging system with joint optical coherence tomography and digital epiluminescence microscopy for point-of-care skin diagnosis.
The Complex Enzymology Of mRNA Decapping
Single stranded RNAs with a free 5′ monophosphate end are susceptible to rapid degradation. Transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) are stabilized by hairpin structures and by “hiding” their 5′ ends within complex protein structures.
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