In their review published in BioEssays, Russell Fletcher, Diya Das and John Ngai discuss how the integration of lineage tracing with data obtained from single-cell RNA-sequencing can provide insights into how stem cells differentiate.
Life Science
Branching Out: Neuronal Growth Modifiers
Using nano-pillars to change the way that neurons grow.
Computational Methods for Analyzing and Modeling Genome Structure and Organization
Recent advances in chromosome conformation capture technologies have led to the discovery of previously unappreciated structural features of chromatin.
From Microbes and Fetal Allografts to a Better Understanding of Cancer Immune Tolerance
In their ‘Think again’ article published in BioEssays, Megan Barnet and colleagues discuss how insights from fetal allografts and microbes can lead to a better understanding of immune tolerance in cancer.
Control of Protein Synthesis During the Integrated Stress Response
The integrated stress response (ISR) is a highly-conserved pathway used by cells to respond to diverse cellular stresses.
Gene Therapy: Virus-like Delivery System Takes the Heat out of Melanoma
Targeted viral-based gene therapies come with their own risks. A new gene delivery system mimics viral therapies to infect cancer cells with vesicular stomatitis virus matrix protein, with a similar transfection efficiency as the virus itself.
Why Dominant Individuals are More Vulnerable to Develop Stress-Induced Depression
Thomas Larrieu and Carmen Sandi discuss whether social rank is a predictive risk factor for stress-induced depression.
Simulating Complex Systems: Agent-based Modeling in Molecular Systems Biology
Mohammad Soheilypour and Mohammad Mofrad discuss a technique termed ‘agent-based modeling’ that is used in systems biology.
Stacking Up: Building Complex Perfused Tissues
An automated system to assemble macrotissues from prefabricated living microtissues with a cell density similar to organs is reported.
New Ultra‐Low‐Cost Smartphone Sensor To Diagnose Autoimmune Disease
American researchers designed a smartphone octo‐channel optosensor (SOS) for low‐cost low‐volume lab tests as a mHealth diagnostic tool.
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