This non-viral CRISPR-Cas9 delivery vector is ten times as effective at genome modification as the standard plasmid transfection techniques, down-regulating Plk1 expression over 70% to inhibit tumor growth.
Life Science
Invader Cells as Delivery Vesicles for Various Cargo Molecules
A smart cell-targeting approach for potential use in specific cell ablation.
New 3D In Vivo Imaging Approach for Functional Assessment of Oviduct
A 3D imaging approach that enables prolonged functional assessment of the mouse oviduct (or fallopian tube) in vivo.
What is a Stem Cell?
Discussing the historical roots of the stem cell concept and the definition generally adopted today.
LARP1 on TOP of Ribosome Production
Ribosome production is a considerable energy investment for the cell—rRNAs and ribosomal proteins (RPs) are among the most abundant classes of RNAs and proteins—and their production must, therefore, be synchronized temporally and stoichiometrically to ensure efficient ribosome assembly.
Making Lineage Decisions with Biological Noise: Lessons from the Early Mouse Embryo
Intercellular communication may provide a mechanism to exploit and buffer cell-to-cell variability.
Finding the Perfect Match: Search for Homologous DNA Sequences during DNA Repair
In his review published in BioEssays, James Haber takes a look at how the ends of a broken chromosome find a template with which to repair such a double-strand break.
BET Proteins and Nrf2: Studying their Interplay May Offer New Therapeutic Opportunities
In their “Hypothesis” article published in BioEssays, Nirmalya Chatterjee and Dirk Bohmann discuss the interplay between Nrf2 and BET proteins and the resultant implications for therapies targeting these proteins.
The Host-Associated Microbiome: A Special Issue in Molecular Ecology
Analyses representing the state-of-the-art in our understanding of the complex host–microbiome relationship are presented.
Selective Protein Immobilization without Purification
Protein immobilization directly from cell lysates is demonstrated in a new process that avoids expensive purification steps but expertly maintains target protein selectivity.
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