A Diamond Nanoneedle Array for High-Throughput Delivery
Here are the top five papers downloaded in August 2013. Also view the August issue of Advanced Healthcare Materials!
Chitin Microneedles for an Easy-to-Use Tuberculosis Skin Test by Jungho Jin, Valerie Reese, Rhea Coler, Darrick Carter and Marco Rolandi
An easy-to-use tuberculosis skin test is developed with chitin microneedles that deliver purified protein derivative at the correct skin depth and result in a positive test in BCG-immunized guinea pigs
Nanovesicle-Based Bioelectronic Nose for the Diagnosis of Lung Cancer from Human Blood by Jong Hyun Lim, Juhun Park, Eun Hae Oh, Hwi Jin Ko, Seunghun Hong and Tai Hyun Park
Olfactory nanovesicles are combined with carbon nanotube field-effect transistors. The nanovesicles recognize lung cancer biomarkers and generate responses through the olfactory signal transduction. The generated responses are converted into electronic signals through the carbon nanotubes. This sensitive and selective bioelectronic nose detects the biomarker from human blood plasma without any pretreatment processes.
Targeting Dendritic Cells: The Role of Specific Receptors in the Internalization of Polymer Capsules by Justine D. Mintern, Chiori Percival, Marloes M. J. Kamphuis, Wei Jin Chin, Frank Caruso and Angus P. R. Johnston
Dendritic cells are an important target for vaccine delivery. It is shown that antibody functionalized polymer capsules can effectively target dendritic cells; however, the internalization is highly dependent on the specific receptor targeted. This work highlights the importance of considering factors such as how the antibody/capsule is internalized, rather than just the target specificity.
Mechanically Robust, Negative-Swelling, Mussel-Inspired Tissue Adhesives by Devin G. Barrett, Grace G. Bushnell and Phillip B. Messersmith
Adhesive hydrogels that negatively swell at physiological temperature are presented. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials are designed that are suitable as medical sealants and adhesives.
Targeting Dendritic Cells: The Role of Specific Receptors in the Internalization of Polymer Capsules by Justine D. Mintern, Chiori Percival, Marloes M. J. Kamphuis, Wei Jin Chin, Frank Caruso and Angus P. R. Johnston
Dendritic cells are an important target for vaccine delivery. It is shown that antibody functionalized polymer capsules can effectively target dendritic cells; however, the internalization is highly dependent on the specific receptor targeted. This work highlights the importance of considering factors such as how the antibody/capsule is internalized, rather than just the target specificity.
Engineering the Regenerative Microenvironment with Biomaterials by Jeffrey J. Rice, Mikaël M. Martino, Laura De Laporte, Federico Tortelli, Priscilla S. Briquez and Jeffrey A. Hubbell
Significant advancements in biomaterial engineering have been driven by our improved understanding of the regenerative microenvironment including the roles of growth factors and cytokines and their interactions with the extracellular matrix to control the healing response. Here, advanced hydrogel scaffolds that are engineered to enhance tissue healing and regeneration are reviewed.
