Soft robotic grippers demonstrate their ability to transport cargoes on demand.
Tales Around the Clock: poly(A) Tails in Circadian Gene Expression
Light is perhaps the main environmental cue (zeitgeber) that affects several aspects of physiology and behaviour, such as sleep/wake cycles, orientation of birds and bees, and leaf movements in plants. Temperature can serve as the main zeitgeber in the absence of light cycles, even though it does not lead to rhythmicity through the same mechanism as light.
The Mechanistic Basis for Chromatin Regulation by Pioneer Transcription Factors
An investigation into how pioneer factors interact with closed chromatin to influence chromatin landscapes and generate differentiated cells.
Waxing and Waning: A Biodegradable Implant
Biodegradeable medical devices made from wax might one day remove the need for surgical implant removal.
Controlling Cells with Light and LOV
The broad applications of LOV domains in optogenetics are reviewed.
Chemically Engineered Fusion Proteins beyond Nature’s Machinery
Bioactive entities are combined into structurally ordered multidomain protein complexes to mitigate selective targeting of a hallmark protein molecule in cancer diseases.
Structure–Function Comparisons and Implications for Genome Editing
Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.
Improving Nanomedicine Tumor Penetration by Design
Rational design of nanoparticles with state-of-the-art strategies can effectively improve the penetration as well as therapeutic efficacy of cancer nanomedicines
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