Recent advances in aptamer-mediated siRNA delivery systems for RNAi therapy ranging from anticancer therapy to antiviral therapy.
Computational Methods for Analyzing and Modeling Genome Structure and Organization
Recent advances in chromosome conformation capture technologies have led to the discovery of previously unappreciated structural features of chromatin.
Machine Learning for Bioinformatics and Neuroimaging
Machine Learning (ML) is a well‐known paradigm that refers to the ability of systems to learn a specific task from the data and aims to develop computer algorithms that improve with experience.
The Mechanistic Basis for Chromatin Regulation by Pioneer Transcription Factors
An investigation into how pioneer factors interact with closed chromatin to influence chromatin landscapes and generate differentiated cells.
Call for Nominations: Biopolymers Murray Goodman Memorial Prize
Submit your nomination for the 2018 Biopolymers Murray Goodman Memorial Prize!
Copy and Paste Genome: A Closer Look at Heritable L1 Retrotransposition
In their review published in BioEssays, Sandra Richardson and Geoffrey Faulkner discuss the origins and implications of L1 retrotransposition events during development.
Evolution of Post-Transcriptional Gene Regulation
“DNA makes RNA makes protein”? After transcription, mRNAs undergo a series of ‘post‐transcriptional’ regulatory processes to be finally translated into functional proteins. Changes in these regulatory processes are important driving forces underlying the evolution of phenotypic differences across different species.
Biopolymers Murray Goodman Memorial Prize Symposium
William F. DeGrado receives the Murray Goodman Memorial Prize at the ACS Spring National meeting 2018.
Structure–Function Comparisons and Implications for Genome Editing
Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.