The Journal of Polymer Science Innovation Award is now in its seventh year, and we are delighted to honor Rachel O’Reilly.
Targeting RNA in Mammalian Systems with Small Molecules
Small molecules have been used to study several mammalian RNA elements in disease. These advances encourage exploration of newly discovered RNA interactions with therapeutic potential.
What is happening in Polymer Science?
Each year, the editors of Wiley’s Macromolecular Journals select the best content published in the journals to be featured in a special collection, the Best of Macromolecular Journals.
Trans-Scale Biosensing Interface for Ultrasensitive Detection [Video]
Dr. Fan Yang and Prof. Guo-Jun Zhang from Hubei University of Chinese Medicine, and co-workers, engineer a trans-scale biosensing interface capable of ultrasensitive microRNA detection.
Genetic Variants in mRNA Untranslated Regions
Discussing the mechanisms of UTR regulation, the role of genetic variants in modulating RNA processing, and protein production in human disease.
Multipartite Designer Nanoparticles for Theranostic Applications
Multipartite designer nanoparticles are formed from the phage lambda decoration protein and can be used in a variety of theranostic applications.
Hematopoiesis in the Bone Marrow Microenvironment: Of Cells, their Interactions, and Therapeutic Opportunities
Recent findings on the roles and identity of the bone marrow microenvironment and how these niches might be targeted in the case of diseases are discussed.
“Golden Age” of Molecular Microbiology: Understanding Freshwater Microbial Communities
In the “golden age” of molecular microbiology, modern molecular tools enable researchers to understand freshwater microbial communities in unprecedented detail by identifying and enumerating them, as well as determining their activity in the environment.
Engage and Move Forwards: Eukaryotic CMG Helicase Leads the Way at Replication Forks
In their review in BioEssays, Huilin Li and Michael O’Donnell discuss recent findings about the structure and function of the eukaryotic CMG helicase.
Therapeutic Applications of Group I Intron-Based Trans-Splicing Ribozymes
Group I intron-based trans-splicing ribozyme specifically recognizes disease-specific RNA, removes the sequence downstream of the target site, and replaces it with a 3’-exon encoding a therapeutic/reporter RNA sequence, inducing therapeutic/reporter activity selectively in the target RNA-expressing cells.