A recent review discusses the intrinsic and extrinsic mechanisms underlying intestinal cell plasticity.
Results for "DNA"
Synthetic Alienation of Microbes
Review by Kubyshkin and Budisa in Biotechnology Journal explores the why and the how.
Chimeric RNAs in Cancer and Normal Physiology
Chimeric RNAs can be generated by not only chromosomal rearrangements at the DNA level, but also intergenic splicing at the RNA level. Chimeric RNAs are demonstrated to be not the elusive features of cancer cells, but also present in normal physiology and with diverse functions.
Mutantelec: A Simulation Platform for Profiling of Proteins
The electrostatic potential of proteins determines their ability to interact with specific biological targets. A recent article discusses the application of a novel tool (Mutantelec) in understanding mutations in the tumor suppressor protein p53 and its consequence.s
Dynamic Enhancer Function in the Chromatin Context
In live cells, many enhancer-binding transcription factors exchange rapidly with their binding sites and leave no footprints in chromatin. Available data suggests a highly dynamic mechanism for enhancer activation, involving numerous stochastic binding events at a target enhancer.
Python-Based Software for Computational Drug Design
New apps and software may bring convenience to our daily lives, but their reach also extends to areas like drug discovery research.
Oral Nucleic Acid Therapy for Gastro-Intestinal Diseases
DNA and RNA (nucleic acids) interference therapies have the potential to treat many human diseases.
Glowing miRNA in vivo
A DNA molecular machine powered by double-stranded fuel strands enables visualization of microRNAs in tumor bearing mice.
Multiplex FRET Biosensor Simplifies Nucleic Acid Detection
Time-gated FRET-based biosensors allow the quantification of multiple nucleic acids at low nanomolar concentrations using just a single donor–acceptor pair.
Shiny New Scissors in the CRISPR/Cas9 Toolbox for Advanced Genome Editing
The CRISPR/Cas9 toolbox has been expanded with fluorescent Cas9 and a dCas9 functionalized with a tag able to activate gene expression that can be transfected to cells directly as ribonucleoprotein complexes (RNP).
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