In her article published in BioEssays, Nora Engel discusses how sex differences become established in early embryogenesis and how analyzing the underlying mechanisms can lead to a better understanding of sex differences in health and disease.
Cover Art: Osteogenesis, Anti‐Inflammatory Nanotherapeutics & Bone Regeneration
Check out the latest covers of Advanced Healthcare Materials!
Baby Steps: How To Make An Egg And Sperm
Knowledge of the processes needed to make precursor cells of eggs and sperm gives insights into reproductive biology and infertility.
Glycogen Synthase Kinase-3 and Alternative Splicing
Sequencing of the human genome led to the surprising discovery that we do not have many more protein coding genes than presumably simpler organisms.
Regulation of Cytoplasmic RNA Stability: Lessons from Drosophilia Fruit Fly
The key players within the pathways of RNA decay are well conserved with their mutation or disruption resulting in distinct phenotypes as well as human disease.
The Mechanistic Basis for Chromatin Regulation by Pioneer Transcription Factors
An investigation into how pioneer factors interact with closed chromatin to influence chromatin landscapes and generate differentiated cells.
Copy and Paste Genome: A Closer Look at Heritable L1 Retrotransposition
In their review published in BioEssays, Sandra Richardson and Geoffrey Faulkner discuss the origins and implications of L1 retrotransposition events during development.
Mammalian X Chromosome Dosage Compensation in the Germ Line
n their review published in BioEssays, Mahesh Sangrithi and James Turner discuss mammalian X chromosome dosage compensation with a particular focus on the germ line.
Chemically Engineered Fusion Proteins beyond Nature’s Machinery
Bioactive entities are combined into structurally ordered multidomain protein complexes to mitigate selective targeting of a hallmark protein molecule in cancer diseases.
New 3D In Vivo Imaging Approach for Functional Assessment of Oviduct
A 3D imaging approach that enables prolonged functional assessment of the mouse oviduct (or fallopian tube) in vivo.