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Immunity to CRISPR Cas9 and Cas12a Therapeutics

Immunity to CRISPR Cas9 and Cas12a Therapeutics

Genome-editing therapeutics introduce foreign nucleic acids and proteins into the circulation and cells, which can activate the innate, cellular, and humoral immunity in human patients. The key obstacle in translating CRISPR therapeutics to the clinic is hence to identify, diminish, and monitor these immunological risks before adverse immune reactions.

Confererence Report: TEDx Berlin

Confererence Report: TEDx Berlin

This year’s edition of TEDx Berlin, entitled “FOCUS”, was held on September 3rd and encompassed three sessions with invited speakers in different topics covering Digital Life and its challenges. Image copyright TEDxBerlin 2017.

Limbal Stem Cells for Treatment of Corneal Blindness

Limbal stem cells have attracted a lot of interest in the field of regenerative medicine because of their unique ability to fully restore the whole cornea upon transplantation. Several important aspects of limbal stem cell biology are reviewed such as limbal stem cell identification, developmental origin and therapeutic potential.