Researchers use enzymes to link antigens and adjuvants, creating safer and more effective vaccines by lowering the required adjuvant dosage.
Small Methods
Tracing life’s origins with early Earth chemistry
What role could non-biological molecules have played in helping primitive biological and chemical systems evolve into their current, complex forms?
Cleaning up ocean microplastics with MagRobot
Specially designed microrobots could help clean plastic waste from water systems.
Flickering shadows of the fine skeleton of a cell
A new method with unprecedented resolution allows researchers to visualize dynamic and elusive mechanisms that underpin essential biological processes, such as cell division.
Small Methods Virtual Issue: Biomaterials and Life Sciences
Highlighting the excellent research being published in the multidisciplinary field of biomedical materials and life sciences.
Virtual Issue in Small Methods: Biomaterials and Life Sciences
The Editors of Small Methods are pleased to publish this special biomedical virtual issue. This collection highlights outstanding research in Small Methods from the very first issue to now, in the areas of biosensing, biomedical engineering, nanomaterials,...
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.
Sampling from Single Living Cells
Nanoprobe-based methods can sample the content of a single living cell without affecting its viability.
Let’s Play Proteins! Microarrays of 3D Assembled Peptide Structures
A method to create arrays of branched peptide assemblies as a surrogate for protein arrays is developed.
Shiny New Scissors in the CRISPR/Cas9 Toolbox for Advanced Genome Editing
The CRISPR/Cas9 toolbox has been expanded with fluorescent Cas9 and a dCas9 functionalized with a tag able to activate gene expression that can be transfected to cells directly as ribonucleoprotein complexes (RNP).
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