The NCI Alliance for Nanotechnology in Cancer program was established in 2005 to accelerate integration of nanotechnology into cancer research and oncology.
WIREs Nanomedicine and Nanobiotechnology
Carbohydrate-Based Nanomaterials for Biomedical Applications
Carbohydrates are abundant biomolecules with a strong tendency to form supramolecular networks.
Recent Advances in Photodynamic Therapy for Cancer and Infectious Diseases
Photodynamic therapy combines light and a photosensitizer to generate reactive oxygen species to induce cellular damage.
Antibody and Antibody Derivatives as Cancer Therapeutics
The immunoglobulin G scaffold can be engineered to increase stability, improve efficacy, and allow novel functionality as a potent anti‐cancer therapeutic.
Applications of Molecular Engineering in T-cell-based Immunotherapies
Harnessing an individual’s immune cells to mediate antitumor and antiviral responses is a life‐saving option for some patients with otherwise intractable forms of cancer and infectious disease.
Stem Cell-Macrophage Interactions with Ferumoxytol and Ferumoxytol-derived Nanoparticles
“Off the shelf” allogeneic stem cell transplants and stem cell nano‐composites are being used for the treatment of degenerative bone diseases. However, major and minor histocompatibility antigens of therapeutic cell transplants can be recognized as foreign and lead to their rejection by the host immune system.
Nanomedicines for Improved Treatment of Ocular Diseases
Understanding the interactions, permeability, and partitioning of drug delivery systems in ocular tissues can improve the drug retention time and bioavailability.
Viruses as Controllable Nanodevices
Physical, chemical, and synthetic virology work together to reprogram viruses as controllable nanodevices.
Gold Nanoparticles to Probe the Biological Obstacles of Nanomedicine
Despite massive growth in nanomedicine research to date, the field still lacks fundamental understanding of how certain physical and chemical features of a nanoparticle affect its ability to overcome biological obstacles in vivo and reach its intended target.
Targeted siRNA Delivery Using Aptamer-siRNA Chimeras and Aptamer-Conjugated Nanoparticles
Recent advances in aptamer-mediated siRNA delivery systems for RNAi therapy ranging from anticancer therapy to antiviral therapy.
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