Every gene found in our DNA exerts its action via the activity of its encoded protein product. However, the synthesis of the protein cannot take place directly from the gene. An intermediate messenger RNA (mRNA) molecule is first produced from the gene via a process...
Deciphering Ribosomes’ Actions in Living Cells
Computational methods and tools to analyze ribosome profiling data.
Engineering RNA Binding Proteins to Improve Human Health
Somewhere in a jumble of protein building blocks may lie the key to unlocking the next generation of therapeutics to improve human health.
A Tail of Two Pathways: Regulation of mRNA 3’ Ends During Cellular Stress
While it might not feel like it, the cells in our body are under constant stress. Cellular exposure to stress such as UV radiation contributes to DNA lesions that the cell responds to by initiating DNA repair pathways. If these lesions are not dealt with, mutations...
microRNA Clusters as Markers for Cancer
MiRNAs area class of noncoding RNA important for gene expression regulation in many plants, animals and viruses.
Unraveling the Hidden Message of RNA
In vitro and metabolic RNA labeling approaches and their applications.
Small, Powerful Players in Regulating Quantitative Yield Traits in Rice
In this WIREs RNA review, the authors discuss the role of different miRNAs controlling yield-related quantitative traits in rice.
Nonsense-Mediated mRNA Decay
The nonsense‐mediated mRNA decay pathway selects and degrades its targets using a dense network of RNA‐protein and protein–protein interactions.
Viral Modulation of RNA Alternative Splicing: A Key Player in Virus-Host Interactions?
Upon viral infection, a tug of war is triggered between host cells and viruses to gain control of vital cellular functions.
Deep Learning for RNA-Protein Interaction Prediction
Hundreds of RNA‐binding proteins and their associated RNAs have been revealed, which enables the large‐scale prediction of RNA–protein interactions using machine learning methods.