Light is perhaps the main environmental cue (zeitgeber) that affects several aspects of physiology and behaviour, such as sleep/wake cycles, orientation of birds and bees, and leaf movements in plants. Temperature can serve as the main zeitgeber in the absence of light cycles, even though it does not lead to rhythmicity through the same mechanism as light.
“DNA makes RNA makes protein”? After transcription, mRNAs undergo a series of ‘post‐transcriptional’ regulatory processes to be finally translated into functional proteins. Changes in these regulatory processes are important driving forces underlying the evolution of phenotypic differences across different species.
Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Small molecules have been used to study several mammalian RNA elements in disease. These advances encourage exploration of newly discovered RNA interactions with therapeutic potential.
Ribosome production is a considerable energy investment for the cell—rRNAs and ribosomal proteins (RPs) are among the most abundant classes of RNAs and proteins—and their production must, therefore, be synchronized temporally and stoichiometrically to ensure efficient ribosome assembly.
The chaperone Hfq speeds up match-making between small regulatory RNA and mRNA in bacteria, helping bacteria respond to stress or changed growth conditions.
Discussing the mechanisms of UTR regulation, the role of genetic variants in modulating RNA processing, and protein production in human disease.
Group I intron-based trans-splicing ribozyme specifically recognizes disease-specific RNA, removes the sequence downstream of the target site, and replaces it with a 3’-exon encoding a therapeutic/reporter RNA sequence, inducing therapeutic/reporter activity selectively in the target RNA-expressing cells.
The identification and understanding of the full range of RNA-binding proteins, with their variety of functions and mechanisms, will be a significant step towards disentangling the complexity of post-transcriptional and translational regulation.
All steps in the RNA life cycle are under circadian clock control.
Quantum entanglement visualized for the first time ever
Scientists take a closer look at rare particles called hypernuclei
French WEST reactor breaks record in nuclear fusion
Researchers take a glimpse at the structure of rare tetraquarks
An anti-inflammatory peptide may hold the key to low-back pain relief
CERN scientists search for new physics in unusual energy patterns linked to hidden particles
Cutting out processed foods doesn’t automatically make a diet healthier
String theory provides a new take on the expansion of the Universe
Could a nuclear explosion set Earth’s atmosphere on fire?
New study reveals surprising impact of screen time on the developing brain