Recent advances in chromosome conformation capture technologies have led to the discovery of previously unappreciated structural features of chromatin.
WIREs Systems Biology and Medicine
Quantitative Systems Models Illuminate Arrhythmia Mechanisms in Heart Failure
Quantitative systems modeling aims to integrate knowledge in different research areas with models describing biological mechanisms and dynamics to gain a better understanding of complex clinical syndromes.
The Mechanistic Basis for Chromatin Regulation by Pioneer Transcription Factors
An investigation into how pioneer factors interact with closed chromatin to influence chromatin landscapes and generate differentiated cells.
Mechanisms of Wnt Signaling and Control
Throughout development and into adulthood, Wnt proteins ensure embryonic patterning, cellular proliferation, cellular identity, and organization of tissues.
Deep Brain Stimulation Therapies in Parkinson’s Disease
From individual neuron models to cutting-edge control approaches, the evolution of computer methods for deep brain simulation (DBS) can lead to personalized DBS therapy.
PharmGKB: A Worldwide Resource for Pharmacogenomic Information
PharmGKB is one of the preeminent worldwide resources for pharmacogenomic information. It is freely available to all users, and provides an interface that is easy to use for researchers, clinicians, and everyday citizens.
Image-Guided Surgery in Cancer: A Strategy to Reduce the Incidence of Positive Surgical Margins
Research into how to better visualize tumor cells during surgery is underway, with a hope of limiting the occurrence of positive surgical margins.
Gene Changes: Chromatin Modifications in Metabolic Disease
Modifications to chromatin are associated with the development of metabolic diseases, including Type 2 diabetes and obesity. There is evidence that these chromatin modifications can lead to long-term disease risk and increased disease risk for offspring.
Blood Group Antigens Affect the Brain-Gut-Microbiota Axis
Human microbiota, blood group antigens, and disease, a look at the ways that microbiota interact with the human body.
Immunity to CRISPR Cas9 and Cas12a Therapeutics
Genome-editing therapeutics introduce foreign nucleic acids and proteins into the circulation and cells, which can activate the innate, cellular, and humoral immunity in human patients. The key obstacle in translating CRISPR therapeutics to the clinic is hence to identify, diminish, and monitor these immunological risks before adverse immune reactions.
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