Pattern regulation, as observed in regeneration and development, enables cells to cooperate toward the creation and maintenance of complex anatomies. This image shows planaria, of which every piece has the information needed to restore a complete planarian target morphology.
Cellular Therapeutics: Small Molecule Signaling, Regulation, and Potential Applications
Small molecules have many important roles across the tree of life.
Metabolism in Cancer Metastasis: Bioenergetics, Biosynthesis and Beyond
Metabolism promotes metastatic progression and supports metastatic cancer cells through diverse, interlinked and overlapping mechanisms.
Metabolic Interactions in Cancer
Cellular metabolism at the interface between the microenvironment, the cancer cell phenotype, and the epigenetic landscape
Crosstalk Between Transcription and Metabolism: How Much Enzyme is Enough for a Cell?
A recent review by Donati, Sander and Link tries to answer this question.
Stability Analysis in Spatial Models of Signaling
Examples of spatio-temporal patterns at different biological length scales.
Image-based Computational Fluid Dynamics in the Lung: Virtual Reality or New Clinical Practice?
Image-based computational fluid dynamics (CFD) predicts airflow in the lungs, providing more sensitive biomarkers of how well your lungs are working.
Dynamic Enhancer Function in the Chromatin Context
In live cells, many enhancer-binding transcription factors exchange rapidly with their binding sites and leave no footprints in chromatin. Available data suggests a highly dynamic mechanism for enhancer activation, involving numerous stochastic binding events at a target enhancer.
The Best Models of Metabolism
This Review outlines the metabolic model design process and discusses the numerous choices for modeling frameworks and mathematical representations.
Imaging Mass Spectrometry for Metabolites of Biological Interactions
Applying mature imaging mass spectrometry (IMS) or combining IMS with other imaging techniques to analyze biological interactions builds a bridge between physiology and ecology and creates a more complete depiction of nature.